Friday, January 19, 2007

ABOUT MESOTHELEOMA

About Mesothelioma

The National Cancer Institute states that: "Malignant Mesothelioma, a rare form of cancer, is a disease in which cancer (malignant) cells are found in the sac lining the chest (the pleura) or abdomen (the peritoneum). Most people with malignant mesothelioma have worked on jobs where they breathed asbestos." Asbestos causes a variety of diseases including fatal cancers such as mesothelioma. At the moment there are no mesothelioma cures, and now workers exposed to asbestos in the 1940's, 50's, 60's 70's, and 80's are getting these diseases in the 2000's due to the long latency period of asbestos disease.

A doctor should be seen if a person has shortness of breath, pain in the chest, or pain or swelling in the abdomen.

The purpose of this site is to assist and empower people who have been diagnosed with mesothelioma, and their families, to best understand their options in coping with this disease. This Mesothelioma Resource Web contains in-depth information on treatment options, coping resources, and the ongoing effort to find a mesothelioma cure.

Before getting into the medical details, it is important to note that mesothelioma has been shown to be caused by exposure to asbestos. Furthermore, internal documents from the files of asbestos insulation manufacturers have been uncovered showing that they were well aware of health implications of their products and that they chose to hide that information from the public and their customers. These companies are now being held responsible for compensating people who contract asbestos related diseases. For these reasons, mesothelioma sufferers and their families can benefit by learning about their legal rights by clicking here for The David Law Firm, P.C.* and then returning to get into the medical information about the disease and treatments.


Incriminating Company Documents

It has been firmly established that many of the corporations who manufactured asbestos insulation knew of the dangers of their product. Memos and other internal company documents have been uncovered from these corporations which show a conscious effort to prevent the truth about asbestos's health impacts from being shared with those exposed to it.

SYMPTOMS OF MESOTHELEOMA

Mesothelomia Diagnosis

A proper diagnosis is essential to a treatment plan.

The National Cancer Institute states that: "Malignant Mesothelomia, a rare form of cancer, is a disease in which cancer (malignant) cells are found in the sac lining the chest (the pleura) or abdomen (the peritoneum). Most people with malignant mesothelioma have worked on jobs where they breathed asbestos."

A doctor should be seen if a person has shortness of breath, pain in the chest, or pain or swelling in the abdomen. If there are symptoms, the doctor may order an x-ray of the chest or abdomen. The doctor may look inside the chest cavity with a special instrument called a thoracoscope. A cut will be made through the chest wall and the thoracoscope will be put into the chest between two ribs. This test, called thoracoscopy, is usually done in the hospital. Before the test, the patient will be given a local anesthetic (a drug that causes a loss of feeling for a short period of time). Some pressure may be felt, but usually there is no pain.

The doctor may also look inside the abdomen (peritoneoscopy) with a special tool called a peritoneoscope. The peritoneoscope is put into an opening made in the abdomen. This test is also usually done in the hospital. Before the test is done, a local anesthetic will be given.

If tissue that is not normal is found, the doctor will need to cut out a small piece and have it looked at under a microscope to see if there are any cancer cells. This is called a biopsy. Biopsies are usually done during the thoracoscopy or peritoneoscopy.

The treatment program depends on the size of the cancer, where the cancer is, how far the cancer has spread, how the cancer cells look under the microscope, how the cancer responds to treatment, and the patient's age and desires.

Click Here for a description of the stages of mesotheleoma.

treatment options

Treatment Options

1. How malignant mesotheliomia is treated?

    As scientists continue to look for a mesotheliomia cure, the following treatments have shown promise in controlling this disease. There are treatments for all patients with malignant mesotheleoma. Three traditional kinds of treatment are used:

  • Surgery (taking out the cancer)
  • Radiation therapy (using high-dose x-rays or other high-energy rays to kill cancer cells)
  • Chemotherapy (using drugs to fight the cancer).
  • Adjunctive Drug Treatment (Non-traditional drugs as part of the cancer treatment).

2. Treatment by stage

mesotheleoma journals

The following is a listing of recent articles about mesothelioma in medical journals that are available through PubMed, a search engine of the National Library of Medicine. The journal title, date, and page numbers follow the title, along with a link to PubMed.

  1. Cytoreduction and intraperitoneal chemotherapy for the management of peritoneal carcinomatosis, sarcomatosis and mesothelioma.

    Click here for abstract

  2. High Dose Radiation Therapy Improves Survival in Patients with Mesothelioma.

    Click here for abstract

  3. Novel Complimentary Therapies Boost Role of Surgery for Mesothelioma Cancer.

    Click here for abstract

  4. Gene-modified PA1-STK cells home to tumor sites in patients with malignant pleural mesothelioma.

  5. Harrison LH Jr, Schwarzenberger PO, Byrne PS, Marrogi AJ, Kolls JK, McCarthy KE
    Department of Surgery, Louisiana State University Health Sciences Center, New Orleans.

    http://www.ncbi.nlm.nih.gov

  6. Combined Resection, Intraperitoneal Chemotherapy and Whole Abdominal Radiation for the Treatment of Peritoneal Mesothelioma

  7. Keohan ML, Chabot J, Fountain K, Antman KH, Taub RN
    Columbia University Divisions of Medical Oncology (MLK, KHA, RNT), Surgery (JC), Radiation Oncology (KF), Columbia-Presbyterian Medical Center, New York, NY

    http://www.cancer.med.umich.edu

  8. Phase I and Pharmacologic Study of Sequences of Gemcitabine and the Multitargeted Anifolate Agent in Patients With Advanced Solid Tumors

  9. Adjei AA, Erlichman C, Sloan JA, Reid JM, Pitot HC, Goldberg RM, Peethambaram P, Atherton P, Hanson LJ, Alberts SR, Jett J
    Department of Oncology, Mayo Clinic and Foundation, Rochester, MN.

    J Clin Oncol 2000 Apr. 8;18(8):1748-1757
    http://www.ncbi.nlm.nih.gov

  10. Pleuropneumonectomy in the treatment of malignant pleural mesothelioma

  11. Grondin SC, Sugarbaker DJ
    Division of Thoracic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

    Chest 1999 Dec;116(6 Suppl):450S-454S
Click here for more journal articles

Click here for the home page

Selected Press Releases

  1. Update on Phase III Program of ONCONASE ® for The Treatment of Patients with Unresectable Malignant Mesothelioma

    Press Release from Alfacell, April 3, 2002


  2. Orphan Drug Designation Granted for Treatment of Mesothelioma and Ovarian Cancer

    Press Release from NeoPharm, Inc., February 14, 2002


  3. Encouraging Survival in Patients With Advanced Malignant Mesothelioma Treated With Alfacell's ONCONASE ®

    Press Release from Alfacell, Jan 22, 2002



Interviews With Mesothelioma Experts

Interviews with mesothelioma doctors, a patient, and an attorney to provide perspective on what mesothelioma is, how it's treated and what it's like to live with the disease. The following are transcripts of those interviews:
  • Surgical Approach to Mesothelioma with David J. Sugarbaker, M.D. -1/4/00
    Dr. Sugarbaker is a world-renowned expert in the diagnosis and treatment of pleural mesothelioma. In this interview, he gives specific information about the disease from initial symptoms to current therapy.

  • Living with Mesothelioma with Belle McGuckin - 9/28/99

  • Belle was diagnosed with mesothelioma in October of 1998. Local doctors in Canada knew little about the disease. But she found hope and help through the Mesothelioma Resource Web that put her in touch with Boston's Dr. David Sugarbaker.

  • New Treatments for Mesothelioma with Roman Perez-Soler, M.D. - 10/26/99

  • Dr. Perez-Soler is an extensively published and well-regarded medical professional with specialties in intermal medicine and medical oncology. He defines lung cancers and talks about the latest treatments.

  • Asbestos Disease with Jonathan David, P.C.* - 05/24/99

  • Once someone is diagnosed with asbestos disease of any kind, legal questions often follow. Jonathan David, P.C.* is an attorney who has represented thousands of people with asbestos-related disease and mesothelioma. He discusses some of the medical and legal issues.

    mestholeoma legal questions and law suites

    Mesothelioma Legal Questions

    Q. Is it financially worthwhile to seek compensation?

    A. Yes, amounts may be very significant, and are often enough to provide care for the patient, as well as financial security for the surviving spouse and family.

    Click here for examples of recoveries made for mesothelioma clients.

    Q. What is the advantage of dealing with compensation issues now?

    A. In most states, a case will settle more quickly if the plaintiff is alive, because those cases receive priority. Additionally, there is no one better suited to establish the facts of exposure than the person who has the disease. It is important to accomplish this while he/she is still strong and able to relate this information. And, all states limit the amount of time after a diagnosis that funds can be made available.

    Q. Why is the asbestos industry required to pay compensation to victims of mesothelioma? As someone who has never filed a claim of any kind, should I feel right about filing?

    A. Yes, you should. It has been proven from internal documents, that the companies who manufactured asbestos-containing products knew of the dangers of their products as far back as the 1920s, yet failed to warn anyone until the 1970s.

    They conspired as an industry to spread false and manipulated medical results so people would be persuaded their products were safe. Many of these companies are now willingly negotiating settlements, which allow the victims and their families to achieve financial security and peace of mind as they deal with the devastating results of mesothelioma.

    To find out more about the history of the “conspiracy of silence” of the asbestos industry, and to read some of the incriminating documents that have been uncovered, Click here.

    Q. How can you prove exposure from so long ago?

    A. People have been exposed to asbestos in many different ways, sometimes unknowingly. Some are exposed on the job or in military service; some are exposed at home. A firm with experience in investigating asbestos exposure has numerous proven methods for finding and documenting a person’s exposure.

    Q. How do I find the right attorney?

    A. Some states do not have attorneys who handle asbestos cases. It is important to make a connection with a firm that is experienced in the claims processes, has a proven track record, a strong network of local counsel, and will also give you personal attention.

    We send an attorney to meet with you at no cost or obligation before you make any decisions. Our firm handles cases nationwide; we currently have clients in all 50 states. We put together a legal team that includes local co-counsel in the state of filing at no additional cost to the client. Click here for a description of the claims process.

    Q. How can we afford to have our claim investigated, filed and represented?

    A. Our firm handles cases on a contingency fee basis. This means that you pay nothing unless we make a recovery for you. You will only pay out of this recovery, and will not have out-of-pocket expenses.

    Q. Where would be case be filed?

    A. Every case is evaluated to determine the geographical options for filing. For instance, a person might live in Oklahoma, have been in the Navy on a ship that docked in California, and been exposed to a product in Texas. We might advise against filing in Oklahoma, where settlements are traditionally lower, and instead suggest filing in California, where, like Texas, settlements may be higher, and case resolution may be quicker. In such cases, we would add local California counsel to the legal team at no additional cost.

    "...He was explicit, factual and honest about what could happen. He was also very accomodating about scheduling the meeting..."

    Q. Are these class actions?

    A. No. Our philosophy is against class actions. Our firm believes in representing one person at a time in their own personal case. In this way, the client’s situation is evaluated and compensated individually, based on its own circumstances and merits.

    Q. How long does it take to resolve these cases?

    A. In many jurisdictions, mesothelioma cases are treated with urgency, and are given high priority. This is particularly true if the client is alive. In addition, we target numerous asbestos manufacturers, and as soon as a settlement with one manufacturer is reached, the funds are dispersed to the client. In this way, the client and his/her family receive settlements along the way, rather than waiting for a single lump sum at the end, thus enabling them to use the money for medical treatment or other personal expenditures while the client is still alive.

    Q. Would this claim be filed against my employer?

    A. Our firm files claims against the asbestos industry, where, in most situations, people with mesothelioma will receive the largest recoveries. If a person has an interest in filing against their employer, we would refer the client to an attorney who handles Workers’ Compensation claims.


    FREQUENTLY ASKED QUESTIONS

    Mesothelioma: Questions and Answers

    Q. What is Mesothelioma?

    A. The National Cancer Institute states that: "Malignant mesothelioma, a rare form of cancer, is a disease in which cancer (malignant) cells are found in the sac lining the chest (the pleura), the lining of the abdominal cavity (the peritoneum), or the lining around the heart (the pericardium).”

    Q. How do you get Mesothelioma?

    A. Mesothelioma is almost exclusive to asbestos exposure. Many people with malignant mesothelioma were exposed in the course of their jobs, or while serving their country in the military. Others were exposed to asbestos in a household environment, often without knowing it.

    Q. How much exposure does it take to get the disease?

    A. Workers with heavy, prolonged exposure are at the greatest risk, however, cases of mesothelioma have been documented with very minimal exposure.

    Q. How long does it take after exposure for the disease to show up?

    A. People exposed in the 1940s, 50s, 60s, and 70s are now being diagnosed with mesothelioma because of the long latency period of asbestos disease.

    Q. How common is mesothelioma?

    A. According to the American Cancer Society, 2,000 to 3,000 people per year in the United States are diagnosed with malignant mesothelioma. Click here for more statistics on mesothelioma. More general cancer statistics.

    The medical journal, Pulmonary Perspectives, has also published an excellent article on the prevalence of mesothelioma. Click here to read “Mesothelioma: An Emerging Epidemic”.

    Q. Is mesothelioma (also sometimes referred to as “asbestos cancer”) the same as asbestosis?

    A. No. Asbestosis is a non-cancerous form of asbestos disease, typified by scarring in the lower lobes of the lungs bilaterally (on both sides). Anyone who has asbestosis should monitor their health regularly, since this scarring can worsen over time. Mesothelioma is a malignancy (cancer) of the pleura, or lining of the lung, or the peritoneum, or lining of the abdominal cavity.

    Q. What are the symptoms of mesothelioma?

    A. Sometimes resembling viral pneumonia, pleural mesothelioma may cause shortness of breath, chest pain and/or persistent cough; some patients show no symptoms at all. A chest x-ray may show a build-up of fluid, or pleural effusion. The right lung is affected 60% of the time, with involvement in both lungs being seen in approximately 5% of patients at the time of diagnosis. Less common symptoms of pleural mesothelioma include fever, night sweats and weight loss. Symptoms of peritoneal mesothelioma may include swelling in the abdomen due to a build-up of fluid (ascites), nausea, weight loss, bowel obstruction, anemia or swelling of the feet.

    Q. How is mesothelioma diagnosed?

    A. While mesothelioma may be suspected through an x-ray or CT scan, it can only be definitively diagnosed through pathological examination of a tissue sample.

    Q. How is mesothelioma treated?

    A. Conventional methods of treatment such as surgery, chemotherapy and radiation may be used (usually in combination with one another). In addition, newer approaches such as photodynamic therapy, immunotherapy, and gene therapy are under investigation. The Mesothelioma Web is an excellent source of mesothelioma treatment options, and also offers information on specialists and the newest clinical trials. Also, look at our asbestos cancer glossary.